Denaverine, benzilic acid derivative, nthuav tawm cov khoom zoo ib yam li phenobarbital-hom microsomal enzyme inducer. Nws exerts ib tug relaxing cawv nyob rau hauv lub prepartum uterus, pab txhawb lub suppleness ntawm tus kwj dej yug me nyuam. Tsis tas li ntawd, nws manifests nto anesthetic, anticonvulsive, me tranquilizing, thiab antipyretic teebmeem.
Hauv cov kws kho tsiaj, Denaverine Hydrochloride pom daim ntawv thov hauv kev tswj cov kab mob myometrial thaum yug me nyuam. Kev siv dav hauv obstetrics thoob plaws ntau lub tebchaws nyob sab Europe, nws ua haujlwm raws li cov khoom tseem ceeb hauv kws kho tsiaj obstetrics kom ntseeg tau tias kev yug me nyuam smoother.
Denaverine hydrochloride ua rau muaj kev cuam tshuam rau cov leeg nqaij du, tshwj xeeb tshaj yog nyob rau hauv lub tsev menyuam ua ntej, txhim kho qhov yooj yim ntawm cov kwj dej yug me nyuam. Tsis tas li ntawd, nws ua rau pom qhov chaw tshuaj loog, anticonvulsive, me tranquilizing, thiab antipyretic zog.
Tom qab subcutaneous, intramuscular, los yog intraperitoneal tswj rau npua, nyuj, thiab yaj, Denaverine Hydrochloride pib nws cov teebmeem nyob rau hauv 15 mus rau 30 feeb. Thaum cov leeg nqaij so tuaj yeem kav ntev li ob peb teev, cov teebmeem analgesic feem ntau pheej mus txog 90 feeb. Tsis tas li ntawd, nws ua tiav qhov kev txiav txim ntawm oxytocin thiab nthuav tawm cov tshuaj tiv thaiv ntxiv nrog morphine. Qhov tseem ceeb, Denaverine tau raug pom los ua kom lub siab ua haujlwm enzyme hauv nas.
Hauv cov nas, tom qab kev tswj hwm qhov ncauj, kwv yees li 33% ntawm qhov tsis hloov pauv denaverine raug tso tawm hauv cov zis hauv 24 teev, nrog cov qib tsawg tsawg tom qab 48 teev, qhia tias tsis muaj qhov cuam tshuam loj hauv lub cev. Cov kev tshawb fawb Metabolism tau nthuav tawm kaum ob qhov metabolites ntawm denaverine hauv cov zis nas, elucidating nws cov txheej txheem metabolic cuam tshuam nrog ester cleavage, oxidative O-dealkylation, thiab N-dealkylation.
Mass spectrometry txheeb xyuas yim cov metabolites, suav nrog benzilic acid, 2, 2-diphenyl-(2-dimethylaminoethyl)acetate, N-demethyl-1 thiab 3, 3-diphenyl-morpholin{{ 9}}ib, diphenylacetic acid, methyl- thiab ethyl-(2-(2-ethylbutoxy)-2, 2-diphenyl)acetate, thiab methylbenzilate. Ntawm cov metabolites no, benzilic acid thiab 3, 3-diphenyl-morpholin-2- ib qho yog cov khoom lag luam metabolic tseem ceeb hauv cov nas.
