Neostigmine Methyl Sulfate yog ib qho cholinesterase inhibitor siv nyob rau hauv ntau yam kev kho mob cov ntsiab lus los txhim kho neuromuscular kis tau tus mob. Nws ua haujlwm los ntawm inhibiting enzyme acetylcholinesterase, uas degrades cov neurotransmitter acetylcholine. Los ntawm thaiv qhov degradation no, Neostigmine Methyl Sulfate nce qib acetylcholine ntawm neuromuscular junctions, yog li txhim kho cov leeg nqaij thiab lub zog.
Ib qho ntawm cov kev siv tseem ceeb ntawm Neostigmine Methyl Sulfate yog thim rov qab cov teebmeem ntawm cov leeg nqaij uas tsis muaj depolarizing uas tau siv thaum lub sijhawm phais. Cov leeg nqaij so no pab txhawb kev ua pa thiab ua kom cov leeg so, qhov tseem ceeb rau ntau txoj kev phais. Tom qab kev phais, Neostigmine Methyl Sulfate yog siv rau hauv cov hlab ntsha los tiv thaiv cov leeg nqaij so, ua rau cov neeg mob rov ua kom cov leeg muaj zog thiab lub zog sai dua.
Neostigmine Methyl Sulfate yog qhov tseem ceeb hauv kev tswj hwm myasthenia gravis, ib qho kab mob autoimmune uas ua rau cov leeg tsis muaj zog thiab qaug zog. Hauv qhov xwm txheej no, lub cev tiv thaiv kab mob tawm tsam acetylcholine receptors ntawm qhov sib txuas neuromuscular. Los ntawm kev ua kom muaj acetylcholine, Neostigmine Methyl Sulfate pab kov yeej qhov kev tsis txaus no, txhim kho cov leeg nqaij thiab txo cov tsos mob.
Cov tshuaj kuj tseem siv los kho postoperative ileus thiab tso zis retention, tej yam kev mob uas cuam tshuam rau ib ntus tuag tes tuag taw ntawm lub plab thiab zais zis cov leeg tom qab phais. Neostigmine Methyl Sulfate txhawb nqa cov leeg nqaij leeg, pab txhawb kev rov ua haujlwm ntawm lub plab zom mov thiab tso zis.
Neostigmine Methyl Sulfate feem ntau muaj nyob rau hauv daim ntawv txhaj tshuaj, haum rau kev txhaj tshuaj, subcutaneous, lossis intramuscular tswj. Cov koob tshuaj sib txawv raws li tus mob tau kho thiab tus neeg mob cov lus teb, yuav tsum tau ua tib zoo hloov kho thiab saib xyuas los ntawm cov kws kho mob.
Thaum ua tau zoo, Neostigmine Methyl Sulfate tuaj yeem ua rau muaj kev phiv los ntawm nws txoj haujlwm cholinergic. Cov kev mob tshwm sim muaj xws li bradycardia (lub plawv dhia qeeb), nce salivation, xeev siab, mob plab, raws plab, thiab tawm hws. Cov kev mob tshwm sim hnyav tuaj yeem suav nrog kev ua pa nyuaj thiab qaug dab peg. Nws siv yog contraindicated nyob rau hauv cov neeg mob uas muaj mechanical obstructions nyob rau hauv cov hnyuv los yog urinary ib ntsuj av tau thiab cov neeg mob hawb pob vim muaj peev xwm bronchoconstriction.
Neostigmine Methyl Sulfate yog ruaj khov nyob rau hauv kev pom zoo cia, feem ntau nyob rau hauv chav tsev kub tswj. Nws feem ntau tau ntim rau hauv ampoules lossis vials rau kev txhaj tshuaj, ua kom nws muaj thiab ua tau zoo hauv ntau qhov chaw kho mob.
Neostigmine Methyl Sulfate yog ib qho tshuaj tseem ceeb hauv cov tshuaj niaj hnub no, tshwj xeeb tshaj yog nyob rau hauv tshuaj loog thiab paj hlwb. Nws lub peev xwm los txhim kho kev sib kis ntawm neuromuscular ua rau nws tseem ceeb rau kev thim rov qab neuromuscular blockade, tswj myasthenia gravis, thiab kho mob tom qab phais. Txawm hais tias muaj peev xwm tshwm sim, nws cov txiaj ntsig hauv kev kho cov leeg nqaij thiab lub zog yog qhov tseem ceeb, qhia txog nws lub luag haujlwm tseem ceeb hauv kev kho mob.
