Taw qhia
CAS Naj Npawb: 356068-94-5
Standard: Hauv tsev txheem
Toceranib yog ib hom tshuaj indolinone receptor tyrosine kinase (RTK) inhibitor. Toceranib nthuav tawm kev ua ub no tawm tsam ntau yam kab mob tshwm sim hauv canine xws li cov qog nqaij hlav hauv hlwb, sib xyaw mammary carcinomas, cov nqaij mos sarcomas, thiab ntau yam myeloma.
Khoom Paub meej
|
Molecular Formula |
C22H25FN4O2 |
|
Molar Mass |
396.46 |
|
Qhov ntom |
1.293 |
|
Melting Point |
>133 degree (lub kaum hli ntuj) |
|
Boling Point |
596.8 ± 5 0.0 degree (Predicted) |
|
Solubility |
DMSO |
|
Qhov tshwm sim |
hmoov |
|
Xim |
daj rau txiv kab ntxwv |
|
pKa |
11.7 0± 0.20 (Tshaj tawm) |
|
Kev cia khoom |
chav kub |
Toceranib (SU 11654; PHA 291639) yog ib qho kinase inhibitor nrog cov tshuaj tiv thaiv qog thiab cov tshuaj tiv thaiv angiogenic, uas tuaj yeem inhibit KIT, VEGFR2 thiab PDGFR.
Daim ntawv thov
Toceranib, tseem hu ua Toceranib phosphate lossis hom npe Palladia, yog ib qho tshuaj molecule me me uas yog tsim los rau tib neeg siv los tiv thaiv qog noj ntshav, tab sis tam sim no feem ntau yog siv hauv cov tshuaj kho tsiaj los kho cov qog nqaij hlav cancer mis. Mast cell hlav yog hom mob qog noj ntshav hauv cov dev, thiab tocereanib tau pom tias muaj txiaj ntsig zoo hauv kev loj hlob qeeb thiab txo lawv qhov loj.
Toceranib ua haujlwm los ntawm inhibiting qee cov enzymes uas koom nrog hauv kev loj hlob thiab kev loj hlob ntawm cov qog nqaij hlav cancer, suav nrog tyrosine kinase enzymes xws li c-Kit, PDGFR, thiab VEGFR. Los ntawm thaiv cov enzymes, tocereanib pab kom qeeb lossis nres kev loj hlob ntawm cov qog nqaij hlav cancer.
Ntxiv rau nws siv los kho cov qog nqaij hlav qog nqaij hlav, tocereanib kuj tau tshawb xyuas rau nws cov peev xwm siv los kho lwm yam mob qog noj ntshav hauv cov tsiaj thiab tib neeg, xws li osteosarcoma, melanoma, thiab cov qog nqaij hlav plab (GISTs). Nws kuj tseem yuav muaj qee yam kev tiv thaiv kab mob thiab tuaj yeem siv ua ke nrog lwm yam kev kho mob qog noj ntshav. Txawm li cas los xij, kev tshawb fawb ntxiv yog xav tau kom nkag siab tag nrho nws cov txiaj ntsig thiab kev txwv hauv cov ntsiab lus no.
Kev Tswj Xyuas Zoo
a) Kev lees paub / Kev Tsim Nyog
b) Instruments calibration
c) Kev txheeb xyuas qhov tsim nyog
d) System Suitability test
e) Sampling plan
f) Standards Management
g) OS
h) ICH Stability program
i) Cov qauv khaws cia
j) Raw khoom tswj
k) Hauv kev tswj cov txheej txheem
l) Kev txheeb xyuas thaj chaw
m) Cov khoom kuaj & ntawv pov thawj
FAQ:
Q1: Yog tias kuv tiv tauj koj, koj puas yuav online thiab teb rau kuv raws sijhawm?
A: Yog, thov koj xav tiv tauj peb. Peb pab neeg muag khoom yuav muab kev pabcuam 24/7 online rau koj.
Q2: Koj lub rooj cob qhia zoo li cas?
A: Tam sim no, Keeb Kwm tau tsim cov naj npawb ntawm cov kev cob qhia thoob ntiaj teb siab GMP, thiab nws tau tsim ua tiav kev tswj hwm kev ua tau zoo raws li ICH Q7 thiab QC kuaj qhov system nruab nrog lub xeev cov khoom siv kos duab.
Q3: Koj npaj cov khoom xa tuaj li cas?
A: Los ntawm Cua lossis Los Ntawm Express.
Cim npe nrov: toceranib cas 356068-94-5, Tuam Tshoj toceranib cas 356068-94-5 manufacturers, lwm tus neeg, Hoobkas
